Endoret® (PRGF) – Fertility
Precision Regeneration for Reproductive Medicine
Endoret® (PRGF) is a cutting-edge, autologous system developed by BTI Biotechnology Institute to support tissue regeneration using a patient's own platelet-derived growth factors. Unlike standard PRP, Endoret® is leukocyte-free, clinically standardised, and activated with calcium chloride — enabling a pure, controlled release of regenerative proteins without inflammatory byproducts.
With over two decades of research and CE-certification for various medical applications, Endoret® (PRGF) is transforming reproductive medicine by offering a science-driven, personalised approach to overcoming fertility challenges.
Fertility Applications
Endometrial Thinness & Implantation Challenges
In cases of persistently thin or non-receptive endometrial lining, Endoret® (PRGF) provides a regenerative solution. Its activated growth factors work to improve tissue quality and endometrial structure, helping to create an optimal setting.
Repeated Implantation Failure (RIF)
Repeated failure of embryo implantation can be deeply frustrating for patients undergoing IVF. A key factor often lies in endometrial receptivity. Endoret® (PRGF), administered via intrauterine infusion, promotes endometrial repair, thickness, and vascularisation. It also enhances the molecular environment to support embryo implantation, offering new hope to patients with a history of unsuccessful cycles.
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As a bioabsorbable implant, RegJoint™ eliminates the need for removal surgeries.
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Why Choose Endoret® (PRGF)?
Activated Growth Factors
Calcium chloride ensures a controlled, impactful release of regenerative proteins.
Leukocyte-Free Formulation
Minimises inflammation and enhances safety and consistency.
Clinically Standardised
Reproducible concentrations backed by robust clinical protocols.
Fully Autologous
100% derived from the patient’s own blood — no donor material, no additives.
Backed by Research
Over 20 years of published studies support its use in fertility treatments.
How it works
Endoret® (PRGF) leverages the body's natural regenerative capacity by isolating and concentrating platelet-derived growth factors (PDGFs) from the patient's own blood. Here’s how the process unfolds:
Blood Collection: A small amount of the patient’s blood is drawn using a standard procedure.
Centrifugation & Separation: The blood is processed in a closed system to separate plasma rich in platelets, while eliminating pro-inflammatory leukocytes.
Activation: Calcium chloride is added to the isolated plasma to activate the platelets, triggering the release of growth factors in a controlled, sustained manner.
Application: The activated Endoret® (PRGF) is then infused intrauterine to enhance endometrial receptivity or to treat tissue deficiencies associated with fertility challenges.
This tailored, autologous therapy encourages cell proliferation, angiogenesis, and tissue regeneration — without introducing foreign materials or unnecessary inflammation
Technical specification
Endoret® (PRGF®) is an advanced plasma-rich growth factor (PRGF) technology, utilising a 100% autologous preparation process to isolate and concentrate platelets and bioactive proteins from the patient’s own blood. This system enables the controlled release of growth factors, optimising tissue regeneration while minimising inflammation.
The process involves a standardized centrifugation protocol, ensuring precise separation of blood components without leukocytes, reducing pro-inflammatory responses. Endoret® (PRGF®) is engineered to be highly versatile, with customisable formulations tailored for specific clinical applications, including liquid, fibrin matrix, and injectable gel forms.
The technology is biocompatible and sterile, meeting rigorous safety and regulatory standards, and can be seamlessly integrated into various surgical disciplines such as orthopedics, oral and maxillofacial surgery, dermatology, and sports medicine. With proven efficacy backed by scientific research, Endoret® (PRGF®) represents a cutting-edge approach to regenerative medicine, providing surgeons with a precise, reproducible, and patient-friendly solution
Clinical Evidence
We provide direct access to key scientific papers that support the clinical use of Endoret® (PRGF) in reproductive medicine. These downloadable PDFs offer insights into its efficacy, safety, and applications in fertility treatments.
Interested in a Case?
Exclusively Distributed by Sovereign Medical in the UK
Sovereign Medical proudly supports UK fertility centres with full access to Endoret® (PRGF), including training, clinical guidance, and regulatory compliance. Whether you're exploring new frontiers in ovarian rejuvenation or tackling complex implantation failure, our team is here to help you integrate Endoret® into advanced reproductive care.
Contact us to arrange a product demo, training session, or clinical consultation.