Unlocking the Healing Potential of Platelet-Rich Plasma – Why Formulation Matters in Fertility Medicine

Platelet-Rich Plasma (PRP) has become a prominent term in regenerative medicine, praised for its ability to stimulate healing using components derived from the patient’s own blood. However, in the intricate field of fertility and reproductive medicine, how PRP is prepared and what it contains matters far more than in other clinical applications. The full potential of PRP can only be realised through specialised, standardised formulations—such as Endoret® PRGF by BTI—that address the biological and technical limitations of generic PRP products.

What Is PRP?

PRP is an autologous blood product in which the concentration of platelets exceeds normal baseline levels. Once activated, these platelets release α-granules containing a wide array of growth factors, cytokines, and signalling molecules essential for tissue repair and cellular communication.

Key components of PRP include:

• Platelet-Derived Growth Factor (PDGF) – Stimulates fibroblast activity and promotes angiogenesis.

• Vascular Endothelial Growth Factor (VEGF) – Supports blood vessel formation and remodelling.

• Epidermal Growth Factor (EGF) – Encourages epithelial tissue repair.

• Transforming Growth Factor-β (TGF-β) – Regulates inflammation and fibrosis.

• Insulin-like Growth Factor-1 (IGF-1) – Aids in cell proliferation and maintains tissue homeostasis.

Limitations of Generic PRP in Fertility Treatments

1. Inconsistent Formulation

   Commercial PRP kits often vary significantly in platelet concentration, white blood cell (leukocyte) levels, and red blood cell contamination. This inconsistency leads to unpredictable biological outcomes.

   
   

2. Inflammation Linked to Leukocytes

   Many generic PRP preparations contain leukocytes, which can release proteolytic enzymes and reactive oxygen species (ROS)—both of which may cause inflammatory damage to sensitive reproductive tissues, such as the endometrium.

   
   

3. Lack of Tissue-Specific Targeting

   Generic PRP is not tailored for applications such as improving endometrial receptivity, supporting angiogenesis, or modulating ovarian function—all of which are vital for reproductive success.

   
   

4. Activation Method Matters

   Some PRP systems use bovine thrombin or synthetic activators, which may lead to immunogenic reactions or inconsistent clinical results.

   
   

The Need for Specialised PRP in Fertility Medicine

For PRP to be truly effective in reproductive health, it must be:

• Pure – Free from leukocytes and inflammatory mediators.

• Standardised – Consistently formulated and regulated.

• Tissue-appropriate – Specifically designed for use in reproductive tissues.

• Clinically validated – Supported by peer-reviewed clinical studies.

This is precisely where Endoret® PRGF by BTI distinguishes itself—offering scientifically developed formulations that are optimised for regenerative use in reproductive medicine.