Conservative & Orthopaedic Surgical

Endoret® (prgf®) has the most experience (over 20 years!) on the market in terms of the development of specific protocols for tissue regeneration, a ground-breaking technique exclusively developed.

Biological characteristics of the formulation

A staggering 20% of Human resource goes into research and development at the institute!

Therapeutic application of Endoret® (PRGF®) in orthopaedic surgery and sports medicine has been revealed as one of the most effective treatments for arthrosis, tendon, ligament, and muscular injuries, as well as in the recuperation of fractures or surgical interventions.

Endoret® (prgf®) four formulations, one product.

Surgical Treatment

  Severe OA Joint Tendon ligament Meniscus ACL Bone Spine
Prgf® graft
Fibrin membrane


  OA Tendon ligament Meniscus Muscle Bone Spine Neutral



Why use Endoret instead of other PRPs?

The Endoret system provides many advantages:
Autologous and rich in Growth Factors
  • No adverse effects or incompatibility risks
  • It promotes homeostasis
  • Stimulates cell proliferation and migration
  • It stimulates the endogenous secretion of proteins from the extracellular matrix
Optimal concentration of Growth Factors

Platelet concentration compared to baseline between 2 and 3 times

Balance between growth factors:

  • Platelet-based (released by platelets)
  • Plasma-based (present free in plasma)
Free from leukocytes and inflammatory proteins
  • Reduces inflammation, pain, and tissue fibrosis
  • Preserves the integrity of the fibrin matrix over time
Controlled activation
  • Promotes the release of growth factors from platelet
  • Induces polymerisation of the fibrin matrix
Dual effect and bioavailability

Endoret PRGF works on tissues with its double action:

  • Immediate, due to the effect of the growth factors at the time of application
  • Prolonged over time, thanks to the fibrin matrix that acts as a reservoir for sustained release
  • Makes it possible to prepare specific formulations adapted to each tissue and clinical need
Security and compliance guarantees

All necessary medical equipment and devices for Endoret closed system technology:

  • They have CE marking for obtaining Plasma Rich in Growth Factors (PRGF)
  • They comply with the most exhaustive quality controls in compliance with the current regulations (control of endotoxins and sterility, etc…)
  • They are composed of biocompatible materials , and with the safety and reliability of medical devices under a quality system of maximum guarantees.
  • They offer high protection to the patient, by meeting the sanitary requirements applicable to products for clinical use.
Scientific evidence
  • Technology endorsed by more than 200 indexed scientific publications

Wide training offer adapted to the different medical specialties

  • Face to face with our specialist team of industry experts
  • Online training portal
  • Webinars

Endoret® (prgf®) – Liquid
This formulation is used to treat:

  • Mild, moderate, and severe osteoarthritis
  • Muscle pathology
  • Meniscus
  • ACL
  • Bone and spine
  • Tendinopathies
  • Ligament pathology
  • It can also be used in combination with the other formulations in surgeries.

The fact that it’s in liquid form facilitates skin infiltration. Activated liquid form that, following tissue infiltration, polymerises in a Fibrin Matrix allowing the balanced and gradual release of a large number of molecules, including growth factors and other proteins.

Endoret® (prgf®) – Clot

It can be used in Orthopaedic Surgery and Sports Medicine in the treatment of:

  • Tendon rupture
  • ACL reconstruction
  • Bone fractures
  • Chondral injuries
  • Joint

The plasma rich in growth factors clot is a Fibrin Matrix that polymerises after controlled activation.

In combination with the other formulations in surgical treatments, it favours tissue regeneration and acts as an excellent system for the balanced and gradual release of a high number of molecules, including growth factors and other proteins.

Endoret® (prgf®) – Graft
The combined graft, made from a plasma rich in growth factors clot and biomaterial, is used in surgical treatments where it is necessary to encourage osteosynthesis:

  • Mixing plasma with biomaterial (autologous bone, de-mineralised bone matrix, autologous cartilage…), allows osteogenic grafts that are easy to transport and handle to be obtained for the reconstruction of bone and chondral defects
  • The plasma rich in growth factors graft can also be used as a “carrier” of a heterologous graft to facilitate its insertion and avoid dispersion around the defect area
  • Tendons and ligaments
  • Bone

Endoret® (prgf®) – Fibrin Membrane

The autologous fibrin membrane has elastic and plastic properties. It is resistant, stichable, easy to handle and fully resorbable. It is used for surgical wound closure, to contain combined grafts and clots and to prevent adhesions.


  • Tendon and ligaments

Who uses Endoret®(prgf®)?

  • Private hospitals
  • Elite Sports clinics with radiologists and specialist physiotherapists
  • Orthopaedic surgeons
  • UK leading training providers in MSK ultrasound guided injections

How well used is Endoret® prgf® in Sports Medicine conservatively and surgically?

Just with football alone, 16 out of 20 premier football teams and counting are being treated with Endoret®(prgf®) in the UK. It is also used in widely outside of the UK too.

Endoret® (prgf®) list treatments the human technology institute has studies and papers on. Endoret® (prgf®) is broadening its studies further, but until the due diligence and publications are ready, the manufacture will not advertise alternative indications.

By working in collaboration with the pioneer and same vision, we look forward to meeting you and deliver your patients optimum results led by science.

Loan Order / product purchase form

New clients: If you do not have a current account set up, please contact us on 01279 816167 or For us to send you a form to register your account.

Urgent orders: Our order cut of times are 2pm – 2.30pm
*Please contact the office of you need a quote for a same day, pre 9 or pre 12 – prices for these may vary


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Conservative and Surgical


Conservative and Surgical


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